The doctors, nurses and patients at the frenetic Accident and Emergency department in the fictional Holby City Hospital, located in the fictional county of Wyvern in the southwest of England.
The daily lives of a medical practice staff at the fictional West Midlands town of Letherbridge, including their often-dramatic involvements with their patients.
Guppy gives his dad an ultimatum; Woody rescues a small boy from a swimming pool and remembers the boy's mother from a sexual encounter; Sam's latest girlfriend is using sex as a tool to obtain his prescription drugs; is a gung ho army sergeant guilty of misconduct?
Fin angers some yobs at a chav estate then his ambulance has brake failure; Tess' teenage son gets a job as Bex's assistant on reception; Ellen interrupts another cosy moment for Abs and Nina.
A gay love triangle involving soldiers and police leads to an attempted monoxide job; Guppy is beaten in the car park by the racist homophobic thugs featured in this and the previous episode.
A cleric with PMT assaults her husband then crashes her car into a construction site triggering a chain of events leading to the death of a child and Abs being assaulted. Harry is granted leave and persuades Tally to go on holiday with him.
Amy has to be fostered since her mum abandoned her. Jerry tells Greg all about Eddy. Helen and George clash over the job in Australia. Greg sees Amy and her jealous new foster sister. Amy starts talking, but what does her future hold?
It is the New Year and Ronnie's niece is still staying, Faith and Greg had a great holiday and Nathan and Tash are loved up. Greg is called out to a chemo patient by her daughter. Mac and Julia inspect the new super practice premises.
Helen visits a new patient in a care home after a mystery call and finds all's not well. George invites everyone to a party where she will make an announcement - which panics Mac and Julia. Ben tries to clear the air with Julia about Liam.
Marc and Helen think about love and loss when she treats an elderly man who won't have a flu jab and he gets involved with the complicated situation of a widow and her lifelong friends living next door. Tom has his appointment at last.
Abs grows increasingly jealous of Greg's relationship with Nina, and is upset when his girlfriend organises a house party. Tess and Sam argue about Mike. UKTV Play.
Nadia is disappointed when Stitch ignores her at work, but his behaviour later on in the day changes her opinion of him, Dixie is jealous as Cyd and Greg prepare for a trip away, but who is she jealous of? While Selena gets a shock.
Guppy takes heroin by mistake after stealing what he thought was cocaine from a patient's pocket. Josh threatens to report Dixie for turning up late to an incident. UKTV.
Valerie says goodbye to an old friend, Daniel and Becky have their first row, and Zara has a patient who seems determined that she find something wrong with him.
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