George Herman 'Babe' Ruth
Marshall Hunt
Jacob Ruppert
Helen Woodford Ruth
Miller Huggins
Claire Hodgson Ruth
Brother Matthias
Lou Gehrig
Judge Landis
Ty Cobb
Eddie Bennet
Emil Fuchs
Jimmy Walker
Lady in Hotel (as Frankie Thorn)
Bill Killefer
Orphan Boy
Jimmy Barton
Dorothy
Umpire
Waite Hoyt
Jumpin' Joe Dugan
Vendor
Julia
Reporter
Hod Lisenbee
Fan
Wally Pipp
Young Babe
Charlie Root
Graham McNamee
Mrs. Woodford
Fred Lieb
Orphan (uncredited)
Baseball Fan (uncredited)
News Reporter (uncredited)