Gary and Wyatt get to meet Dr. Frankenstein who is not happy that they did a much better job of bringing someone to life than him. He drains all of Lisa's energy to create the bride of Frankenstein.
After all the brain power at Farber is sucked out by a magic brain vacuum, Gary must outwit a giant orb formed by the brain power that wants to take over the world.
When Chett can't get a job, Lisa creates the store "Man's Man's World" that specializes in his favorite things: cigars, monster trucks, beef jerky and paint-ball. It is run by two former rats who with Chett's help plan to take over the world.
Gary and Wyatt get stuck in 1969 when Lisa loses her memory and thinks she is a hippie. Chet is also there and tries to correct the mistakes of Richard Nixon's presidency.
Wyatt and Lisa show Chett what life would be like if Wyatt was never born. Not only does everyone have a better life, but Lisa can't bring her and Wyatt back.
After Gary and Wyatt get credit for saving an airliner, Lisa is unhappy that she can't go to the ball being thrown in their honor. She sneaks in and she and the President fall in love.
After Chett swallows an invitation to a rave, Lisa miniaturises herself, Gary and Wyatt and the three of them travel through Chett's body à la Fantastic Voyage (1966).
Chett wishes to be trapped on a desert island and things go way wrong. Lisa goes trapped with him, they're in the Bermuda triangle, her magic doesn't work and a hurricane is coming.