The character of "Bubbles", played by Andre Royo, was largely based on a real Baltimore drug addict and police informant who went by that name. The real Bubbles, who would slur his speech much more than the fictional character, first started working with the cops near the early 1960's after being arrested for a burglary. He spent the next few decades as an informant, leading to the arrest of several hundred felons and getting paid at least $50 for each one caught. His near-photographic memory and ability to blend into the scene made him one of the best in the city. Eventually he would start using the hat method portrayed on the series, where he acted as if he was selling hats and would place one of a certain color on the head of those the police should arrest.

While filming, Andre Royo was once approached by a Baltimore resident, who handed him a package of heroin and said he looked like he needed a fix. Royo calls this his "street Oscar."

Many of the minor characters are played by real-life police officers, politicians and former criminals. In fact, many of the former criminals who act on the show were previously arrested by the real-life cops who act on the show.

According to Michael Kenneth Williams, he secretly struggled with a cocaine addiction during the third season. He never missed a day of work nor was he ever late. He also suffered with an identity crisis and severe anxiety due to his popularity as Omar.

The character of 'Bunk' Moreland is based on real-life Baltimore detective Oscar 'Rick'/'The Bunk' Requer. The real 'Bunk' also constantly chomped on a cigar and had a taste for fashion.

According to David Simon, HBO almost cancelled the series during its third and fourth seasons. He had to literally beg the network to keep it on the air.

Senator Clay Davis' catchprase "Sheeeeee-it" didn't appear in the script. It was added by Isiah Whitlock Jr..

Entertainment Weekly included Omar Little in its list of the "16 Ultimate TV Antiheroes" at position #3 in the July 15, 2012 issue, after Walter White (Breaking Bad) and Tony Soprano (The Sopranos) as #1 and #2 respectively.

By the time the series had enough critical clout and rabid fandom to legitimately justify another season, David Simon was working on Treme (2010). However, when Attorney General Eric Holder, yet another powerful fan of the show, gently joked in 2011 that he'd like to see another season, he received a not-so-joking response from Simon, who retorted "we are prepared to go to work on season six of The Wire if the Department of Justice is equally ready to reconsider and address its continuing prosecution of our misguided, destructive and dehumanizing drug prohibition." As of 2017, the two sides still appear to be at a stalemate.

According to Andre Royo, "The Mayor hated us because he thought we made Baltimore look bad. He told the cops to come down on us for anything: jay walking, resisting arrest, loitering. People got arrested, production was postponed sometimes coz people were locked up; people went missing for a couple of days at a time. But it was a crazy time, it was amazing, the most exhilarating moment of my life."

Stephen King called Snoop "perhaps the most terrifying female villain to ever appear in a television series".

The character of Avon Barksdale is loosely based on Melvin Williams. Williams was a notorious drug kingpin in Baltimore who was brought to justice by Ed Burns. Williams joined the show as the deacon in season 3.

In preparation for the role of Bodie, J.D. Williams walked around Baltimore's inner city during the middle of the night a few days before the first taping; talking about this to AllHipHop, Williams stated "it was like 12 or 1:00 in the morning. I just threw on a black hoodie and walked around. I went to one of their hoods and watched that night. I learned not to do that no more, I was lucky I made it back that night."

Michael Kenneth Williams got the role of Omar after one audition.

The writers/producers briefly considered doing a sixth season about the influx of Latinos into Baltimore, but none of them knew enough about Baltimore's Latino population to write about it so the idea was dropped.

As Idris Elba and Dominic West had little exposure to the American market before The Wire, many viewers, even Baltimoreans, were shocked to learn the actors were actually British.

Although eight actors are billed in the opening credits for all 60 episodes, Daniels is the character who actually appears in the most episodes, 58 out of 60.

When Dominic West first auditioned on videotape from his London home, he tried to have his girlfriend read the lines for the other characters in the scene, but her English accent kept throwing him off and he kept laughing. So West performed the scene himself by leaving pauses where the other character's lines were supposed to be. West admits to imitating Robert De Niro for his audition. At first, the producers found the audition tape "weird" and "comic" but they reconsidered when they concentrated on West's performance. When West was offered the role, he became reluctant because the contract was for five seasons. But his agent convinced him that the show would not last more than one. It ended up lasting five seasons.

Lance Reddick auditioned for the roles of Bunk Moreland and Bubbles before being cast as Cedric Daniels. He was told that they were looking for "a name" to fill the Daniels role.

Bubbles was based on a real police informant known as "Possum", whose true identity has not been made public at the request of his family. Possum was noted as having an incredible memory for faces, and was often very helpful in pointing out drug dealers to police. David Simon met with him twice, shortly before Possum's death from AIDS, intending to write an article about him. He ended up turning it into an obituary.

Omar is the only character to not use major profanity. Michael Kenneth Williams was even given permission to remove any curse words from his dialogue if any mistakenly got put in.

Stringer's name is a composite of two real Baltimore drug lords, Stringer Reed and Roland Bell. His story bears many similarities to the life of Kenneth A. Jackson-specifically, his crossover from the illegal drug trade to legitimate business ownership and political contributions.

Lawrence Gilliard Jr. (D'Angelo Barksdale) and Michelle Paress (Alma Gutierrez) later married. Because they were on the show at different points, their characters never met.

Clark Johnson , who plays newspaper editor Gus directed both the pilot and the last episode of the show.

Michael Kenneth Williams expressed that his relationship with and love of off-Broadway New York theatres, such as the National Black Theater in Harlem gave him the skill set needed for his portrayal of Omar; in particular using the Meisner technique to create Omar from the ground up, immersing himself by researching details of inner city Baltimore. The role presented a particular challenge as it was the first major recurring television character he had played.

The scars on both Michael Kenneth Williams and Jamie Hector's faces are real.

The character of Sgt. Jay Landsman played by Delaney Williams was based on Jay Landsman, a real-life Sergeant with the Baltimore County Police. He was featured in David Simon's book "Homicide: A Year On The Killing Streets". Landsman himself joined the cast in the third season playing Lt. Mello.

As Michael Kenneth Williams's attempts were deemed too ineffectual, Omar Little's trademark whistle of "A Hunting We Will Go" was actually provided by Susan Allenback.

Sonja Sohn would gather relevant members of the cast to memorialise any character who was killed off. This began after she learned she was supposed to be killed off and fought for her character's life.

Tray Chaney originally auditioned to play the character of Wee-Bey Brice but the producers felt he was too short. They were so impressed with his audition that they created the character of Poot for him to play.

Michael B. Jordan did little preparation for the part of Wallace, but used his experiences growing up on the streets of Newark, New Jersey, as a way to prepare for the role. Jordan said, "I live in an area where there are lots of drug dealers and I know some people who may or may not sell drugs, so this is not new to me."

David Simon said he inserted quite a bit more humor into the show than was really warranted, just to keep it from being too depressing for anyone to watch.

The producers wanted to keep a documentary-type atmosphere. Therefore, aside from the ending montage at the end of each season and a few exceptions, no musical score is used in the series. The music had to be coming from a stereo, boombox, etc. i.e. it had to be diagetic.

Tom Waits - composer of the show's title theme, 'Way Down In The Hole' - agreed that The Wire's producers could make use of the song provided they first let him see the show. Videotapes were promptly dispatched to the Waits household, followed by weeks of agonising silence. When the execs finally got the courage to give the legendary singer-songwriter a call, Mr Waits explained that he'd received the cassettes but he couldn't play them because he didn't know how to operate his VCR. "My wife knows how to use it and she'll be back in a couple of days," Waits continued. Two days later, a release was signed.

At a reunion of some of the cast in 2014, it was revealed that the actors weren't all that satisfied with the show at first. "I told my agent to call Law & Order (1990)," said Wendell Pierce; Sonja Sohn said, "A lot of us were like, 'I don't know, it's kind of slow.'"

Marlo Stanfield was based on Timmirror Stanfield, a major Baltimore drug trafficker. In 1986, Stanfield was 25 and ran a gang which included over fifty members. The Stanfield gang controlled South Baltimore's Westport area and West Baltimore's Murphy Homes housing project. The gang committed multiple murders and drew the attention of authorities, who were able to persuade fifteen witnesses to testify. The core of the gang was convicted.

Jay Landsman auditioned for the character based on himself before being cast as Dennis Mello.

Omar was originally supposed to appear in only seven episodes before being killed off. He proved so popular with fans and critics alike that the writers changed his arc to make him a major character throughout the show's run, although David Simon denies that there was ever any plan to kill him off in the first season.

A spin-off was planned during pre-production on the fourth season. It was to be titled "The Hall" and focus solely on the politics storyline but HBO ultimately rejected the idea.

According to Lance Reddick, creator David Simon explained to him in great detail his character plot throughout the whole series when they were shooting the pilot.

Sonja Sohn's role in the series led to her current work as the leader of a Baltimore community initiative called ReWired for Change. The program is run out of the University of Maryland School of Social Work and uses episodes of the series as a teaching tool, encouraging the participants to examine and query their lives and past actions. Other actors and writers involved with the series serve as board members.

This is Barack Obama's favourite show and his favourite character is Omar. He said, "That's not an endorsement. He's not my favourite person, but he's a fascinating character."

According to Sonja Sohn, during the first season she had much trouble remembering her lines causing numerous delays. She says it was due to childhood trauma of growing up in a ghetto and witnessing police brutality. Because of this she was uncomfortable in the neighborhood while filming took place and had issues with portraying a police officer.

In an online interview, David Simon stated that Ziggy is loosely based on a real stevedore named Pinkie Bannion whose antics have become a local legend around the docks. According to Simon, Bannion "used to take his duck to the bar and repeatedly expose 'pretty boy' and all else. As they said in Bawlmer about Pinkie: 'That boy ain't right.'"

Chris Bauer wore a fat suit to give Frank Sobotka sufficient girth.

The picture on Frank Sobotka's dartboard is of Bob Irsay, the owner of the Indianapolis Colts who moved the team from Baltimore in the middle of the night in late 1983.

Robert F. Chew, who played Proposition Joe, selected and mentored many of the child actors.

Michael Kenneth Williams has stated that he pursued the role of Omar because he felt it would make him stand out from other African Americans from Brooklyn with acting talent because of its contradictory nature.

Prez's experiences as a teacher are based on those of Ed Burns, who became a Baltimore middle school teacher when he retired from the Police.

Some of the show's interiors, including McNulty's apartment set and the police station's offices, were constructed inside a former Sam's Club Warehouse store. The zoning for that building dictated that its tenant had to be a retail business, and when the producers got into trouble for renting the building without selling anything from it, they considered opening a store there to sell t-shirts, DVDs, and other show souvenirs before the issue was finally resolved.

David Simon has described his goal of presenting McNulty as ambiguous in his motivations. Based on his experiences with real detectives, he feels that most crime dramas present their police characters with the falsehood that they care deeply about the victims in the cases they are investigating. Simon states that in his experience a good detective is usually motivated by the game of solving the crime - he sees the crime as an "insult to his intellectual vanity" and this gives him motivation to solve it.

Jamie Hector has commented that he sees Marlo Stanfield as striving to obtain power rather than profit and revelling in using that power over others and that much of his performance stems from trying to capture Stanfield as a man of power and economy using minimalist movement and speech.

The character of Blind Butchie was inspired by a case that David Simon covered in his book "Homicide: A Year on the Killing Street". Patrolman Gene Cassidy was shot in the head at point blank range with a .357 Magnum handgun. Although initially expected to die of his injuries, Cassidy made a partial recovery but was left blind and without his sense of smell or taste. A drug dealer named Butchie Frazier was eventually convicted of attempted murder in the first degree.

D'Angelo Barksdale's name is a tribute to Donald Angelo Barksdale, the first African-American player of the ABA/NBA team Baltimore Bullets.

Felicia Pearson was discovered by Michael Kenneth Williams at a Baltimore club. He invited her to come to the set one day and he introduced her to the writers and the producers, and after subsequent auditions, she was offered a role in the series.

Prez's code-breaking ability, and the season 1 pager code itself, are based on the Melvin Williams case investigated by Harry Edgerton and Ed Burns.

The haunting tune that Omar whistles is supposed to be "A Hunting We Will Go" rather than "The Farmer in the Dell." The latter erroneously appears in some subtitles and discussions.

This is Eminem's favorite show, as stated by the rapper in a 2009 interview. In fact, Dominic West even appears on a skit on Slim Shady's album, Relapse.

Lance Reddick turned down the role of Mr. Eko on Lost (2004) in order to do this show.

None of the characters appear in all episodes.

The journalist characters of the fifth season were mostly based on real-life employees of The Baltimore Sun during David Simon's tenure as a writer for the newspaper. Scott Templeton is based on Jim Haner, a Sun reporter whom Simon believes fabricated stories. James Whiting is based on former Sun editor John Carroll. Thomas Klebanow is based on former Sun editor Bill Marimow. Rebecca Corbett, Tim Phelps, Steven Luxenberg, and Jay Spry are all based on former co-workers with the same names. Staff writer William F. Zorzi, a former Sun reporter, plays himself. Simon based Gus Haynes on himself.

David Simon has said that Clay Davis is based on three different politicians in the Maryland State Senate, and that his affectionate use of the word "partner" is based on one of them, saying that everybody in Baltimore knows who this is.

James Ransone, is a Baltimore native and has described Ziggy as representative of the difficulties people face just trying to get by in Baltimore. The character's creators have deemed him "the angry prince of goofs."

David Simon's books "Homicide: A Year on the Killing Streets" and "The Corner" (written with Ed Burns) both mention the real Dennis Wise. He is described as one of the two most infamous contract killers active in Baltimore during the late 1970s - Vernon Collins being the other. Police were frustrated by the fact that no witnesses could be found against either man. Neither Wise nor Collins would break under intense police questioning, refusing to say anything other than to request a lawyer. Dennis Wise was eventually sentenced to life in prison in 1979 for a contract killing. He earned his bachelor's degree in Psychology while in prison. In 1999, Maryland Correctional officials transferred Wise to an Arizona prison in Yuma because he was allegedly leading an influential prison gang. Wise wrote a novel called The Wolf Trap while in prison.

Michael B. Jordan auditioned before casting director Alexa L. Fogel in New York City for the role of Bodie. He was called back twice and the auditions went well, but he was turned down for the part because Fogel thought he was too young. The part went to Jordan's friend J.D. Williams, who grew up in the same hometown with Jordan in Newark, New Jersey.

Seth Gilliam auditioned for the role of Stringer Bell before being cast as Ellis Carver.

Jimmy McNulty was originally named Jimmy McArdle but because no one liked the name, executive producer Robert F. Colesberry suggested renaming him.

Rawls' distinctive manner of intimidating subordinates is based on real-life Baltimore CID commander Joe Cooke. David Simon has also commented that Rawls' attitude towards the murder rate and his unit's clearance record is a product of the extreme pressure he is under.

Robert F. Chew recalled that when he auditioned, the other actors were all well groomed, well dressed and thinner than he was. He later learned that the real-life inspiration for the character was a charming and debonair drug dealer so he was surprised to have received the role. He was initially unsure as to how long the character would remain in the series and so he was pleased to be one of the few characters from the drug world who appeared in all five seasons.

David Simon originally wrote the crime family featured in season two as Italian-based. However, to avoid comparison with The Sopranos, also on HBO, Simon changed it to a Greek mob.

There was no improvisation on set. The scripts were followed verbatim, and any possible change was discussed with David Simon first.

To prepare for the role of Omar, Michael Kenneth Williams was told to familiarise himself with two classic westerns - The Wild Bunch (1969) and The Man Who Shot Liberty Valance (1962).

In season three, when McNulty is comparing the units skills favorably to those of other Baltimore police he mentions Donald Worden as one of the few police who can match them in skill. Worden is a real life detective who served in the Baltimore homicide unit when David Simon covered it. For at least part of that time he was the partner of Jay Landsman, who plays Dennis Mello and was the inspiration for the character of the same name.

Gbenga Akinnagbe auditioned for the role of Marlo Stanfield before being cast as Chris Partlow.

By the end of shooting for season 1, the producers realized that shooting for subsequent seasons should take place mostly on the eastern side of Baltimore because of the lack of trees. Without as many trees in the frame, the passing of the seasons (Fall, Winter, Spring & Summer) during a running season of the show wouldn't interfere with the continuity of the story.

Tristan Mack Wilds auditioned for the role of Randy Wagstaff before being cast as Michael Lee.

Dominic West had a lesser role in season four due to theatre work and wanting to be closer to his family.

Jamie Hector auditioned for the role of Cutty Wise before being cast as Marlo Stanfield.

Isiah Whitlock Jr. auditioned for the role of Lester Freamon before being cast as Clay Davis.

David Simon has said that Omar is based on Shorty Boyd, Donnie Andrews, Ferdinand Harvin, Billy Outlaw and Anthony Hollie, Baltimore stickup men between the 1980s and early 2000s who robbed drug dealers. In an episode in season 3, Avon asks Slim Charles about available muscle to help them and he inquires about the name "Shorty Boyd", a nod to the former stick up man. Andrews later reformed, got married and helped troubled youths. In season 4, he plays one of the two men Butchie sends to help Omar in prison, in the episodes The Wire: Margin of Error (2006) and The Wire: Unto Others (2006) and Omar later meets up with him at Blind Butchie's in The Wire: That's Got His Own (2006) while planning the big drug robbery. Andrews died at age 58 in New York City on December 13, 2012 after suffering an aortic dissection.

Wee-Bey Brice was based on a hitman named Vernon Collins, AKA Bey-Brother, who worked for a heroin dealer named Thomas H. Taylor. He was described by one FBI informant as a "narcotics hit man who is feared throughout the narcotics underworld in Baltimore." Collins is mentioned in David Simon's book "Homicide: A Year on the Killing Streets" as one of Baltimore's notorious contract killers in the late 1970s along with Dennis Wise (who spawned a character of the same name.) Wee-Bey is a reference to this hit man and drug trafficker. Collins was arrested in 1987 and sentenced to thirty-five years in prison.

Tristan Mack Wilds (Michael Lee) and Jermaine Crawford (Duquan Weems) are second cousins.

According to the series bible, McNulty has a college degree in philosophy.

Domenick Lombardozzi speaks with the accent of his native South Bronx, which producers did not believe Lombardozzi would be able to convincingly hide and so did not ask him to try, planning a future explanation as to why the character was policing in Baltimore. Ultimately, in the fifth season premiere episode, The Wire: More with Less (2008), Herc mentions having come from the Bronx when he makes a reference to his hometown New York Yankees being historically more successful than the Baltimore Orioles.

Andre Royo almost turned down the role of Bubbles: "In my mind, there were two problems: 1) I didn't want to play stereotypical character, it could be the kiss of death for my up and coming career and 2) I didn't think I could do better than what I'd already seen and as an artist, if you don't think you can do better than what has already been done then why bother? Luckily I had a strong manager, he said 'they're not offering you the part, they're offering you an audition. Come in and do it'. I met them, and realised that it felt like something different, they weren't trying to be general cop show and they were making sure that no one came across as a gimmick."

D'Angelo Barksdale originally lived with his grandmother and collected fancy footwear. He also had a sister who abandoned two children on him.

The only original piece of score used in the show is Blake Leyh's "The Fall," which plays at the very end of every episode and through its credits.

The series was remastered in 16:9 high definition in late 2014 with the approval of creator David Simon. Although Simon has stated he considers 4:3 to be the correct aspect ratio of the series, he had it shot simultaneously in 4:3 and 16:9 for future-proofing. Simon worked with HBO to paint out film equipment and crew members, and correct sync problems with actors in the new frame.

According to the book Difficult Men, which chronicles the rise of modern television, one role research ride-along that ended with Seth Gilliam (Ellis Carver) and Domenick Lombardozzi (Herc) ducking gunfire in the backseat of a police car. On another, Wendell Pierce (Bunk Moreland) reported seeing "a guy with a knife still in him" as well as a cop trying to take a man who'd been shot downtown for questioning instead of to a hospital.

Donnell Rawlings was considered for the role of Omar before being cast as recurring character Damien Price.

In season one, two detectives, Augustus Polk and Patrick Mahon - were assigned to the Barksdale detail. The names "Polk" and "Mahon" are a play on "pogue mahone," the anglicized version of an Irish expression meaning "kiss my ass." "Póg mo thóin" (pronounced pogue moh hone) was also the original name of Irish folk-punk band The Pogues, whose music is used throughout the series.

In most episodes, subpoenas are issued by "Larry W. Shipley, Clerk of the Circuit Court." Mr. Shipley is, in reality, the former Clerk for Baltimore's neighboring county, Carroll County.

According to the series bible, Herc was originally a steroid abuser.

Two public people connected to Baltimore who are mentioned in the show have run in 2016 Presidential primary elections unsuccessfully. They are Democrat Martin O'Malley and Republican Ben Carson.

Anwan Glover auditioned for the roles of Marlo Stanfield, Fruit and Drac before being cast as Slim Charles.

Many of the cast were in another HBO drama Oz (1997). J.D. Williams, Seth Gilliam, Lance Reddick, and Reg E. Cathey were featured in very prominent roles, while a number of other notable stars of The Wire, including Wood Harris, Frankie Faison, John Doman, Clarke Peters, Domenick Lombardozzi, Michael Hyatt, Michael Potts and Method Man appeared in at least one episode.

Dominic West was reluctant to do the series since it meant signing a five-year contract to live in Baltimore. His agent eased his fears by telling him "don't worry, it'll only last one season."

Stringer Bell was originally named Stringy.

Ray Winstone was offered the role of Jimmy McNulty, but turned it down. Winstone liked the show but did not want to be away from his family for seven months of the year, which was the filming schedule.

Much like its sister show Homicide: Life on the Street (1993), contains numerous references to David Simon's book "Homicide: A Year On The Killing Streets". For instance, the opening of the very first show is lifted directly from the book.

Ranked #8 on Empire magazine's 50 Greatest TV Shows Of All Time (2008).

A fictionalized version of the events of the 1999 Baltimore mayoral election were presented in third and fourth seasons. Many saw the connection between Carcetti and Martin O'Malley, an Irish-American Baltimore City Councillor who was elected mayor, defeating two African American opponents. David Simon denied that the character of Tommy Carcetti was supposed to be O'Malley. David Simon did acknowledge that O'Malley was "one of several inspirations" for Carcetti. He further stated that while Carcetti was "reflective" of O'Malley, Carcetti was a composite drawing aspects from other local politicians that he had covered when he worked as a reporter for The Baltimore Sun.

Johnny Weeks is based on a young white homeless addict that David Simon met while researching "The Corner". This man would follow Simon's subject, drug addict Gary McCullough, around.

Throughout the series the street dealers gave their drugs "brand names" inspired by pop culture and current events. More than 40 different names are heard over the course of the series, including Pandemic, Purple Haze, WMD and Trump Towers.

J.D. Williams is older than the teenage Bodie by eight years.

In the first scene after the opening credits, Jay Landsman tells his officers that Colonel Raymond Foerster has died of cancer. Actor Richard De Angelis, who played Foerster, really did die of cancer in the middle of the film recordings.

George Pelecanos is given credit with creating the character of Dennis Wise, based on unused notes from his novel "Drama City", about a man getting out of prison after almost two decades. The idea reflected the "reform" theme of the third season, so the character was added.

Omar Little made his first appearance of most seasons in the third episode. The exception would be season 3, where he first appeared in the second episode.

Jermaine Crawford auditioned for the role of Michael Lee before being cast as Dukie Weems.

According to the series bible, Lester is a widower. This was not mentioned in the series.

David Simon said that Avon Barksdale is a composite of various Baltimore drug dealers. He is likely based, to some extent, on at least two notorious Baltimore drug dealers: Melvin Williams (who plays the character of The Deacon) and Nathan Barksdale.

D'Angelo Barksadale is Avon Barksdale's nephew. In reality, Lawrence Gilliard Jr. is only two years younger than Wood Harris and a year older than Idris Elba.

A picture of former Baltimore Colts owner Robert Irsay is pinned on Frank Sobotka's dartboard. Irsay moved the Colts from Baltimore to Indianapolis in 1984. He is one of the most hated sports figures in Baltimore.

Michael Kostroff originally auditioned for the part of Frank Barlow before being cast as Maurice Levy.

Lord Jamar was offered the part of Omar. But he turned it down because he refused to play a homosexual character.

Reg E. Cathey auditioned for the roles of Cedric Daniels and Lester Freamon. He was later cast in the show's fourth season as Norman Wilson.

David Simon cast Jamie Hector as Marlo Stanfield based on his performance in Five Deep Breaths (2003).

Appeared on Time magazine's list of the "All-Time 100 TV Shows" by critic James Poniewozik in the September 5, 2007 issue.

Avon Barksdale was originally named Aaron.

According to the proposed settlement agreement received by Jimmy McNulty in Season 2, he and his soon-to-be ex-wife married on August 3, 1999 in Gatlinburg. Tennessee. They had two sons (Michael Barnes McNulty, born November 3, 1997) and Shawn James McNulty (born June 22, 2000)

David J. Smolar, who appears in the final episode of season 3 as a reporter talking to Councilman Gray, previously appeared as the piano player in a restaurant scene between D'Angelo and his girlfriend in episode 5 of season 1. Smolar performed the piano music heard in that episode, a posthumous Chopin Etude and later movement 2 of Beethoven's Pathetique Sonata.

Michael Santangelo was described in the original series outline as having a gambling addiction. This was not mentioned in the series.

Clarke Peters had previously co-starred in The Corner (2000), which was also co-created by David Simon. Delaney Williams also had a small role.

Dominic West's original audition tape for the part was recorded with him as the sole actor leaving spaces for the lines that would be spoken back to him. The producers were amused by the tape and agreed that they had to give him an audition.

Judge Daniel Phelan was originally named Judge Clifford Watkins and was black.

Wood Harris (Avon) and Michael B. Jordan (Wallace) would later co-star in Creed (2015).

The Rotation, as mentioned in The Wire, refers to the process by which Detectives are assigned cases, given an allotted amount of time to resolve the matter, and then must be available for new cases when it arises.

Deirdre Lovejoy (Asst. State's Atty. Rhonda Pearlman) & Pablo Schreiber (Nick Sobotka) also worked together on Orange Is the New Black (2013) as Chris Maser & George 'Pornstache' Mendez respectively.

Lance Reddick (Daniels) and Clarke Peters (Lester) were co-starred in John Wick (2014), but had no scenes together.

Reg E. Cathay was the only actor to have a role in Homicide: Life on the Streets, Homicide: The Movie, The Corner, and The Wire. In addition to appearing in these David Simon shows, he also appeared on Oz, which was a project produced by Barry Levinson. He won an Emmy for his portrayal of Freddy in House of Cards, another series that was filmed in Baltimore city.

Six actors from The Wire appear in The Walking Dead (2010): Chad L. Coleman as Tyreese, Lawrence Gilliard Jr. as Bob Stookey, Seth Gilliam as Father Gabriel Stokes, Brandon Fobbs as Terry and Vincent M. Ward as Oscar, and Merritt Wever as Denise Cloyd.

Michael B. Jordan (Wallace) and Reg Carthy (Norman Wilson) would later play father and son in Fantastic Four (2015).

Rhonda Pearlman's first name was originally named Janelle.

The names of McNullty's sons are the same as Chief Brody's in "Jaws" (Sean and Michael).

Lester Freamon's last named was originally Weeks.

Frankie Faison (Burrell) and Gbenga Akinnagbe (Chris Partlow) later played father and son in The Good Wife (2009).

Robert F. Chew had previously appeared on HBO's The Corner (2000) (created by David Simon) and NBC's Homicide: Life on the Street (1993) (based on a book by Simon). He received all these roles through the Pat Moran casting agency.

Wendell Pierce and Seth Gilliam previously starred together in the Law & Order: Consultation (1992) (S3E10).

Robert Wisdom (Bunny Colvin) and Gbenga Akinnagbe (Chris Partlow) subsequently co-starred in Law & Order: Special Victims Unit: Hell (2009).

Senator Clay Davis' last name was originally Dawkins.

In an unusual move for a police series the officers almost never fire their guns. Only one police officer, Prez, ever fires his gun on the show and in all three cases it is a mistake. The first time he accidentally shoots the squad room wall. The second time he drunkenly fires a shot into the air and then (compounding his gun mistakes) uses it to pistol whip a teenager, blinding him in one eye. The third time he mistakenly shoots an undercover cop.

In season four Dominic West, the ostensible star of the series, requested a reduced role so that he could spend more time with his family in London. On the show it was explained that Jimmy McNulty had taken a patrol job which required less strenuous work.

According to David Simon, Idris Elba took Stringer's death very hard and that he had to assure Elba that he was talented enough get other roles.

Although Cheese Wagstaff and Randy Wagstaff have the same last names, it is never stated that they are related. David Simon has since confirmed in interviews that Cheese is Randy's father. Simon planned to reveal this in a fifth season episode but never got to do so, since the final season was shortened.

Kima was supposed to die in the first season. HBO executive Carolyn Strauss urged David Simon not to kill her off, telling him it would be a mistake.

Producer Robert F. Colesberry also plays Detective Ray Cole. After Colesberry died tragically following routine heart surgery, the Ray Cole character also died from a heart related illness in the show. The entire cast participated in an elaborate detectives wake in honor of Cole and Colesberry's memory.

Dennis Lehane revealed that he was given the duty of writing Omar's death scene in The Wire: Clarifications (2008) specifically because none of the other writers wanted to be known as the guy who killed Omar.

Throughout Series 1, the character of D'Angelo Barksdale struggles with his life in crime, metaphorically claiming he "needs some air" and "can't breathe". He is strangled to death in Season 2.

The original character outline for Bubbles mentions that he is slowly dying of AIDS, a character aspect that was given to Bubbles' friend Johnny Weeks.

When John Doman found out that Rawls was gay, he went to David Simon and told him not to hold back, that he would go as far as they wanted to play that side of his character. The funny thing is that Rawls' homosexuality barely matters on the show.

According to a David Simon audio commentary, Chris Partlow was a victim of molestation, explaining his ferocious attack on Michael Lee's stepfather.

Michael B. Jordan found out his character was going to be killed one week before it was filmed.

Marrimow is a character who is known for his hostile and punitive commanding style in Season 4 who doggedly pursues Herc's badge because he doesn't like him. Marimow (minus one "r") is also the name of one of the editors during David Simon's time at The Baltimore Sun