Wife Angie Lopez is played by Constance Marie, whose birth name is Constance Marie Lopez.

Masiela Lusha (Carmen) was the only member of the main cast to not be of Latin descent--she is Albanian.

Masiela Luscha left the show after the 5th season so she could go to college.

The character "George Lopez" was ranked #18 in "TV Guide"'s list of the "50 Greatest TV Dads of All Time" (20 June 2004 issue).

Ernie, played by Valente Rodriguez, wears a wedding ring in the intro of each episode. He is an unmarried man in the show but is often seen going on dates.

In every episode a new inspirational saying is written on the chalkboard on the side of the kitchen refrigerator.

Belita Moreno also plays a Mexican grandmother to a grandson named Max in the Disney Channel show Wizards of Waverly Place (2007).

During an appearance on The Sharon Osbourne Show (2003) George Lopez revealed it was his wife who first suggested Constance Marie for the role of George's TV wife Angie.

In the earlier seasons of the show Belita Moreno, who plays George's mother, can be clearly seen wearing some heavy "age" makeup. This may be due to the fact that she is only ten years his senior. Later the makeup shows up less, most likely after the audiences accepted Belita as his mother.

Constance Marie, who is of Mexican descent, plays George's Cuban-American wife. William Marquez, who is Cuban, plays George's Mexican-American father.

Emiliano Díez (Vic) is 12 years older than his on-show daughter, Constance Marie (Angie)

Scenes taking place in Carmen's room reveal that she is a fan of Linkin Park, 3 Doors Down, Josh Groban, Green Day and Alanis Morisette.

In Season 2 Episode 13, "Super Bowl", after Benny's brother Joe dies, it is said that Benny is the only one left (having been preceded in death by her mother, father and then her brother). However, in Season 6 Episode 4, "George Testi-Lies for Benny", George contacts Benny's mother to testify at her trial.

Benita is the name of George Lopez maternal grandmother, who raised George after he was abandoned by his parents.

George Lopez' daughter has had several guest appearances on the show.

In Season 2 Episode 14, "The Valentine's Day Massacre", as well as in many other episodes it is mentioned that George and Angie went to (and dated) at the same school in California. However, when Angie's dad Vic moves to California it is insinuated that Angie was raised in Florida, as she was born in Miami.

Esai Morales and Lou Diamond Phillips from La bamba both have guest starred on George Lopez but in different episodes

In the episode "George Drives The Batmobile" George Lopez provides the voice of the drive-thru attendant.

The show's theme song, "Low Rider", is performed by War. In one episode there is a live version of the song.

In the series Carmen is an aspiring poet. Masiela Lusha, who plays Carmen, is actually a poet.

Constance Marie's character (Angie Lopez) couldn't possibly have gone to the same high school with her husband (George Lopez) unless her family had moved from Miami to L.A. and then moved back; this is a story problem never fully addressed throughout the series.

This show has similarities to George Lopez's life.

The episode "Kidney Stays in the Picture" is based on George Lopez's real-life battle with kidney disease.

In one episode George gives Angie a coupon for a Cuban vacation which is dated for years in the future with George stating that by then Castro will have died on November 25, 2016 Castro would die at the age of 90.

George had a father named Manny Lopez who died

Despite the fact that the family's name is "Lopez" George is the only character that plays himself