Belén Rueda left the series in season 6 in order to focus on her film career. She later returned for the series finale.
Several actors from Los Serrano have worked before in another series, "Al salir de clase" (1996): Fran Perea (Marcos), Alejo Sauras (Raúl), Elsa Pataky (Raquel) and Leticia Dolera (Ruth).
Antonio Molero is only 11 years older than his son in the fiction, Alejo Sauras, and Belén Rueda is only 12 years older than her daughter in the fiction, Verónica Sánchez.
Most of the songs in the series are preformed by Fran Perea (Marcos), Santa Justa Klan (the music group composed of the youngest actors in Los Serrano) and El Sueño de Morfeo.