(at around 1h 8 mins) On May 4th, 2007, while promoting the film on The Tonight Show with Jay Leno (1992), Thomas Haden Church revealed that he broke three knuckles during the subway scene where he swings to punch Spider-Man and ends up punching a chunk of the wall away. Church said that the effects crew had told him that the brick in the middle was fake while the upper and lower ones were real. Unfortunately, the foam brick had not actually been put in place yet, and when Sam Raimi yelled 'action', Church spun around and punched the real brick on the first take.
Sam Raimi was deeply unhappy with how the film turned out. He had hoped that the planned fourth film would have made up for it.
According to James Franco, they had to go back and do some reshoots just prior to the release, because test audiences felt that there was not enough action in the film.
Bryce Dallas Howard performed her own stunts during the crane accident scene, unaware that she was pregnant at the time of filming.
All of the screams Kirsten Dunst had for this film were recycled from Spider-Man (2002) and Spider-Man 2 (2004).
Emma Raimi: (at around 2h) The girl who sells her camera to J. Jonah Jameson for $100 is Sam Raimi's daughter.
Christopher Young: (at around 42 mins) the conductor and the guy standing next to the piano player at Mary Jane Watson's rehearsal scene.
Grant Curtis: (at around 49 mins) producer appears as one of the two security guards in the truck that got hijacked by Sandman.