Goofs

When Neville is closing the windows after Anna and Ethan are in his apartment, his shirt changes from long sleeve white to dark short sleeve, then back again when he leaves the room.

When Robert Neville has his flash backs with his family in their SUV a zombie smashes his face against the window creating a blood splatter mark on the passengers window. But in a later flashback the blood splatter is gone.

When Col. Neville is ensnared by the Alpha Male there is no line attached to the taxi cab.

If you look out of the car window on the driver's side (at roughly the 3:18 mark) just after Neville grabs his gun, you will see a silver and red car parked (silver on left, red on right). Neville continues driving down the road and away from the parked cars, but at around the 4:00 mark, when you get another clear shot out his window (over his shoulder), you can see the same two cars parked, yet he is not in the same area where they first appeared.

In the opening scene, Neville's carbine has a sling attached. After the deer he is aiming at gets attacked by the lion, the carbine no longer has a sling.

The central spans of the Brooklyn and Manhattan Bridge are destroyed, but the towers and side spans remain standing which is impossible. If you cut the suspension cables, the whole bridge will collapse. The towers are not strong enough to hold the cables - the weight of the side spans will pull them down.

When Neville opens the drawer in his lab and grabs the grenade, it is shown as a fragmentary grenade. However, when he sets it off, it explodes in a burst of flame. Fragmentary grenades explode without large flames and throw shrapnel. The explosion shown would have been from an incendiary grenade, which looks like an aerosol canister and not the rounded frag grenade.

A genetic immunity to a virus does not come with antigens from which a cure could be made. Typically, it means the immune subject lacks some specific bonding site that a virus uses to attack its host.

The sight on Neville's carbine is a US ACOG sight, yet, when the camera shows the view through the sight, the reticle is from a Soviet PSO-1 sight and some other eastern block sights. There is no ACOG sight with that reticle.

In the scenes with the crowd on the bridge, none of the soldiers are wearing unit patches or any other customary insignia.

Neville is able to drive around the city after three years of isolation. Gas starts degrading in three months in the tank of the car, but in a closed tank (such as those at a gas station) it can be kept for several years. The degradation is due to the fact that it evaporates and mixes with oxygen, but that doesn't happen in an airtight tank.

When Robert Neville goes to sleep the first night, he is adamant about shutting all reinforcements on the windows. Yet when he wakes up in his bed in the morning, we see the sun shining in through the unbarred windows. As proved later in the film, he cannot remove the barriers from the windows until dawn has broken properly.

The hand grenade Neville pulls out in the end scene has a blue arming spoon. Only dummy grenades have blue arming spoons, meaning the grenade isn't a real one.

After Neville hits the first golf ball, the camera pans around the aircraft carrier. At the end of the street on the left of the screen, between the on-ramp and the white building, there is a quick shot of a vehicle moving right to left.

All the flags shown hanging from various buildings in New York City are in perfect condition. These flags would have been torn and faded from three years of hanging in the weather.

During the beginning scenes, where the camera pans over the city, during one pass over a road that runs horizontally across the picture, if you look closely people can be seen walking close to the buildings.

Robert Neville, according to his radio broadcasts, is transmitting on all AM frequencies. In the United States, that would take 116 transmitters. This would be an impossible task to set up and to maintain, while trying to save the world from this virus. A decent antenna for each of these transmitters, such as a dipole, would range in length from 275 to 867 feet. The power to keep these transmitters operating would be a waste of Neville's resources, regardless of their size.

It appears highly unlikely that the military would use an airstrike to demolish New York's bridges. It presents unnecessary dangers such as the risk of the bombs missing their target or creating flying debris, both possibly killing civilians and government personnel. The most likely way in which the bridges could be 'blown' would be to conventionally demolish them with hand-laid explosives instead.

When Robert Neville goes to sleep the first night, he is adamant about shutting all reinforcements on the windows. Yet when he wakes up in his bed in the morning, the sun is shining in through the unbarred windows. As proved later in the film, he cannot remove the barriers from the windows until dawn has broken properly.

At one point in the movie, the character of Robert Neville is rendered unconscious by a blow to the head while hanging upside down. When he regains consciousness after several hours, he is seemingly unaffected by this injury. Furthermore, as the film progresses, he appears to have suffered no lasting effects from his head trauma, not even a transient headache, and the injury is never addressed again.

In reality, Neville would almost certainly have suffered a severe concussion or another form of traumatic brain injury, resulting in an array of debilitating symptoms, including confusion, loss of coordination, nausea, vomiting, seizures, amnesia, and cognitive difficulties. Even in the best-case scenario, he would certainly have experienced terrible, constant pain and likely other impairments.

Several times when Dr. Neville is in his black uniform Jacket, it appears that he is wearing the gold oak leaves of a major, not the almost white silver oak leaves of a Lt. Col.

Neville states the lab doors are made of Plexiglas (acrylic), but when Alpha Male smashes them, the sound is that of breaking glass.

When Neville fires his gun (a Colt Law Enforcement Model 6920 Carbine) at the Dark Seeker in the house and runs out of ammo, the weapon can be heard clicking several times. An AR-15 type weapon will not click when the magazine runs empty. The bolt carrier group will lock to the rear holding the hammer down; pulling the trigger has no further effect.

The sounds made by the fleeing whitetail deer are elk noises.

The clip from Shrek (2001) mixes images and sound from different scenes.

When Neville is in the dark warehouse looking for Sam, he enters a bathroom. When his flashlight hits a mirror, he ducks and shields the light, but there is still a circle of light from the camera behind him.

When Robert Neville is about to enter the dark area to chase after Sam, and as he is swinging his gun from side to side, for a split second, a camera's shadow can be seen sweeping towards the left as he is doing so.

Neville is shown to cover his tracks when entering his home by pouring bleach or ammonia on his steps when he was going inside for the night. This was apparently meant to cover his scent from the dogs used by the infected for tracking and security. This makes no sense for several reasons: 1) This would render his dwelling the only place in the entire city that smelled differently than the others, thus revealing its unique nature. 2) It would do nothing to remove his scent from the door leading into the home. 3) It would do nothing to obscure his scent leading up to the steps themselves.

Robert Neville goes to a lot of effort to try and cover his tracks when he returns to his apartment but since the infected are obviously everywhere in Manhattan to include near his apartment, as we hear them come out at night into the streets growling, moaning, and yelling, it's obvious they must be dwelling nearby where he lives and it would seem that although they can't come outside during the day, they can certainly look out windows of buildings they are in near where he lives and hear his car pull up outside his apartment and see exactly where he lives.

While Neville is trying his serum on the infected female subject, he reads off her vital signs which include a core temperature of 106° Fahrenheit. A sustained core temperature of this level would cause significant and irreversible brain damage, making a cure moot.

On the opening scene, on the interview, the reporter seems to not know the results of Dr Alice Krippin and is also surprised when coming to the conclusion that she had cured cancer. In fact, a research with such results would had them public way before an interview and wouldn't have been published in such way.

All the Dark Seekers appear to have a very active case of rabies. They also appear to be living with this disease for quite some time. Since they are all non-vaccinated they wouldn't have lived for three years since the virus started.

Robert Neville tells Anna that there were 6 billion people on Earth, 90 percent were killed by KV outright (5.4 billion) and that there was one percent immunity. From that he arrived at twelve million immune and 588 million Dark Seekers. However, if calculated from the 600 million remaining (the ten percent that did not die outright) one percent would be six million, not twelve million, leaving 594 million dark seekers, not 588 million. The numbers he arrives at would be correct with 2 percent immunity.

In the lab, when Anna is looking at the pictures of the Dark Seekers, many of these pictures are obvious duplicates.

When Zoe Neville fails the virus screening at the Brooklyn Bridge checkpoint, Lt. Col. Robert Neville gives a direct order to the soldier administering the test, demanding that he repeat the test. Robert may have outranked the soldier, but failing the requirements of the chain of command, the soldier would not be required to obey the order.

At one point one can see Neville train doing pull-ups and running, and one can safely assume he has a solid body and enough strength inside him. However, when he is snared, it takes him a huge amount of effort to climb up to the rope and cut himself loose. Also, since he supposedly is a science laboratory and military expert, one would assume he would know how to handle a pocket knife, such that he would not get into a situation where the knife accidentally lands in his own leg, injuring him, after removing himself from the snare.

Neville hands Anna a CD of Legend: The Best Of Bob Marley And The Wailers and says it is the greatest album ever made. But since it is a best of compilation this could not be possible.