Directed by Brian Henson, the son of Jim Henson who famously conceived The Muppet Show (1976) and the Muppets.

Sesame Workshop sued the team behind the film for the tagline, "No sesame. All street," claiming that the film tarnishes their reputation.

This is the first theatrical film Brian Henson has directed since Muppet Treasure Island (1996).

The title chosen for the Italian release is a spoof of Tarantino's "Inglorious Basterds". In Italy, the title was changed to "Pupazzi senza gloria", which translates to "Inglorious Puppets".

This plot is similar to Who Framed Roger Rabbit (1988), in which cartoon characters live in a real world with humans.

The screenplay was based on a story treatment that had been going around the Jim Henson Workshop for decades, but wasn't produced until 2018 for its obvious adult-oriented themes.

At one point, Katherine Heigl was reportedly to star.

Rupert Gregson-Williams was originally hired as the composer.

Brian Henson's worst day on set was when he decided to direct a scene from inside a trash can. While he was in there, he suddenly felt something creeping down his back. As it turned out, a crew member who thought it was a real trash can had carelessly thrown in a half-full bottle of liquid.

This film also represents two TV Shows The Muppet Show (1976) and Sesame Street (1969).