Jim Rhodes / War Machine (voice)
Mary Jane Watson
Newscaster (voice) (as John F. Beard)
Kingpin
Dr. Curt Conners (voice)
Cletus Kasady / Carnage (voice)
Additional Voices (voice)
Aunt May Parker (voice) (archive footage)
Debra Whitman (voice)
Dormammu (voice) (archive footage) (as Edmund Gilbert)
Dr. Ashley Kafka (voice)
Felicia Hardy (voice)
Tony Stark / Iron Man (voice)
John Jameson (voice)
Baron Mordo (voice)
Madame web
Detective Terri Lee (voice)
Robbie Robertson (voice)
Rhino (voice)