Guybrush Threepwood (voice)
The Ghost Pirate LeChuck / Sheriff Fester Shinetop (voice)
Governor Elaine Marley (voice)
Stan the Salesman (voice)
The Voodoo Lady / Carla the Swordmaster (voice)
Meathook (and His Tattoo) (voice)
Otis the Prisoner / Red Skull the Cannibal (voice)
Bridge Troll / Freddy - Man of Low Moral Fiber / Jojo the Monkey / Meathook's Parrot / Piranha Poodle / Pirate Leader II / Rat / Spiffy the SCUMM Bar Dog (voice)
Alfredo Fettuccini / Bob the Ghost Pirate / Lookout / Ghost Priest (voice)
Bill Fettuccini / Estervan - the SCUMM Bar Pirate / Pirate Leader I / Store Keeper / Sword-Head Ghost (voice)
Mancomb Seepgood / Captain Smirk / Navigator Head / SCUMM Bar Cook (voice)
Biff the Ghost / Franklin - Man of Low Moral Fiber / Herman Toothrot / Swordfight Opponent I (voice)
Narrator / Pirate Leader III / Shifty Melee Citizen (voice)
Cobb - the SCUMM Bar Pirate / Lemonhead the Cannibal / Mystery Pirate I / Swordfight Opponent II (voice)
Bouncer / Sharptooth the Cannibal / Phineas - Man of Low Moral Fiber / Mystery Pirate II (voice)