The photo of the 1990 Red Buick LeSabre shown to Nichols was actually the result from an internet search. The photo was taken in 2007 and is public domain. If you google 1990 Red Buick LeSabre you'll find the exact same photo used in the film.
Grant Singer's feature film directorial debut. Singer has directed several music video and one documentary film, Shawn Mendes: In Wonder (2020), but Reptile (2023) is the first narrative film that he has directed.
Benicio Del Toro and Alicia Silverstone had previously appeared together as love interests in Excess Baggage (1997).