- Mild
- Joel and Tess flirt a little.
- In the 'Left Behind' DLC (which is not a part of the main game), Ellie finds a skull toy, which is basically a magic 8 ball. At one point Ellie asks it, "Am I ever going to get boobs or what?"
- There is a comedic scene where Ellie finds a porn magazine (played for laughs and nothing is shown).
- Some female clickers have a breast out with a hard to see nipple.
- Near the end of the game a character talks about a teenage character possibly getting raped and murdered.
- Ellie nearly gets sexually assaulted. A grown man gets on top of her and says "why don't you try beggin?" He proceeds to put his hands around her throat, but before anything happens, Ellie grabs a knife and kills him.
- David is clearly attracted to Ellie, and is awkward with and around her. At some point, he arguably attempted to rape her.