Daphne's friend Lisa is about to turn 18, and is going to inherit a hotel. Unfortunately the hotel is located on Great Skull Island, where vampires are said to 'live'. The gang is asked by the ferry captain to take a large box to the hotel - which turns out to be a coffin carrying a bat. After loading the coffin the gang heads for the hotel, but behind them in the road, a vampire appears and laughs mockingly. After meeting up with Lisa and the hotel's owner, her Uncle Leon, Daphne and Velma are forced to trade rooms with Lisa for size reasons while Fred, Shaggy and the Scooby brothers take the room opposite them. The vampire invades Daphne and Velma's room, but before he can attack Velma catches him in the act and he is forced to flee. After warning Lisa and Uncle Leon about the vampire, it's discovered that the vampire may in fact be Lisa's long-dead grandfather. While Shaggy and the Scooby brothers are guarding Lisa, they are attacked by Lisa - who has become a vampire. They manage to escape her but find themselves cornered by 'Gramps the Vamp', and manage to lose him by hiding in the coffins. Now the gang must try to trap the vampire and rescue Lisa.
—medic249a2