The film was announced less than a month after the release of the first installment.

This is the second installment (after Sicario (2015)) in a proposed trilogy.

Denis Villeneuve could not return to direct this sequel due to scheduling conflicts with Arrival (2016) and Blade Runner 2049 (2017).

The first installment in the series was titled "Sicario," a Spanish word that translates to "hitman" in English. "Soldado" in English means "soldier."

Isabela Moner had to chop her long hair into a short pixie hairstyle for this film. The video of the haircut is on her YouTube channel. She donated the hair to charity.

Jeremy Saulnier was considered to direct this film but left, due to scheduling conflicts with his other movie Hold the Dark (2018).

Lionsgate was originally going to distribute this film in the United States, but a disagreement between them and Black Label Media made the distribution rights change from Lionsgate to Columbia Pictures. The same happened with Only the Brave (2017).

Third action movie for Josh Brolin in 2018, after Avengers: Infinity War (2018) and Deadpool 2 (2018).