Adam and Danielle Busby defy all odds by giving birth to the first set of all girl quintuplets in the US. After four months in the NICU, the quints come home and along with four-year-old sister Blayke, turn Adam and Danielle's lives upside down.
Adam & Danielle struggle to keep up with the demands of the quintuplets while also making time for 4-year-old daughter, Blayke. Later, a baby photo shoot with the quints turns into pure chaos when Grandma Mimi shows up late to help.
Adam returns to work, leaving Danielle to care for the quintuplets and Blayke by herself for the first time. On Adam's first day back, Hazel falls ill with a fever, leaving the family scrambling and Danielle feeling overwhelmed and alone.
Adam and Danielle realize they need a larger home, but house hunting proves stressful when they realize what a larger house will cost. Later, the family heads back to their hometown and Danielle comes up with an idea that could solve all their problems.
