Skimpy-dressed girls, and one flattering sexual reference from one of the girls' to Warren G's privates, talking about how big it is.
The lyrics are about the realities of street life, but in the video there are some fairly graphic clips from "Above the Rim." The most graphic being a stabbing scene (won't say which one as it would give away plots).
No references to drugs in the song itself, but the video has a scene from "Above the Rim" in which a drug deal is done.
The song is fairly intense and about the realities of life in South Central. Fairly intense.