Excellent series, you'll laugh and cry at the same time. First of all, let me tell you that I haven't watched a TV series in ages (the last one I remember watching is "Brideshead Revisited" – a BBC production - back in 1981).
I have to say I can't stand any of today's series – either American, British or Italian. I hate medical, detective and police series; in a word - all the popular series of these days, since they are all incredibly violent and gory – at least, for me.
One evening I was idly zapping in front of the television when I found one of the first episodes of "Brothers and Sisters": I was pleasantly surprised since the characters were not annoying, nor impossibly beautiful; the plot was not silly like "Friends" and, most of all, there was a certain true-to-life atmosphere that made me continue to watch.
So I borrowed the whole series from the library and I am now watching episode 80, something I would have never imagined. First of all, as I wrote, I like all the characters, especially Sally Field who is an incredible actress (like some other reviewer said, she is one of the best actresses ever).
She can make you feel all of her emotions (whether she's happy, sad, anxious) and I think she's just great in her role as a mother who is always anxious for her children (she reminds me of the typical Italian mother).
At times, she's just adorable with all her weaknesses and sometimes you wish you could enter the screen and embrace her. She can make you laugh and cry at the same time, especially when her heart is broken (look at her face when Simon leaves: she deserves an Oscar for that alone). You can see her all enthusiastic about a new date, as if she was a teenager, and you genuinely feel sorry for her when her expectations are disappointed.
Then there's Kitty; she too is adorable (I confess I had seen her only in a couple of episodes of "Ally McBeal" but didn't like the series), whereas I like her here a lot. I find her a very good actress and she gives us a multifaceted character with all her strengths and weaknesses.
All in all, all actors are very good and likable, you get to love each one of them for different reasons; let me just mention the very good Rachel Griffiths, who really surprised me (I saw her some 15 years ago in "Muriel's Wedding" and would've never expected such career).
(Edited just to add how much I like Matthew Rhys and Dave Annable as well. Matthew is not only handsome but incredibly fun, I can't wait to see him in other films/series).
I would also like to mention the work of the directors, which I find excellent: I like the pace and the rhythm, they manage to keep the attention of the viewer very high all the time. Plus, I like the fact that even the most dramatic moments are alternated with some humour. Last, but not least, we have some groundbreaking issues (at least, here in Italy) like a homosexual couple, two men kissing, the surrogate mother, and so on. Now that I'm approaching the end of the series, I wish there was another one similar to this one!