Watchable but uneven I gave this a 6/10, which in my book is "a movie that was more interesting than most mainstream Hollywood dross, but not good enough that I would bother watching it ever again".
I didn't have a problem with the acting, and the pacing was pretty good. What really let the movie down was the plot.
In particular the thing that bugged me most was it's a movie about a doctor performing operations. Could they not have avoided the giant plot hole of just how unrealistically they portrayed that?
For example, Mary turns up and performs plastic surgery on someone. With no preparation. I'm pretty sure most doctors would want to read up on an operation they hadn't done before. She is also somehow an anaesthesiologist as well as a doctor, so knows the correct dose of animal anaesthetic to give a human.
Not unrealistic enough for you? How about when Mary and one other guy cut off two people's arms and swap them? In her living room. No nurses, no blood transfusions, hell, not even a bucket of ice. Just cut them off and sew them back on again. Yeah, maybe it is that simple and awesome doctors can do stuff like that with no complications whatsoever and no nurses or anything to help, but I felt like I shouldn't have to suspend my disbelief like that for this movie.
Other points that annoyed me: * Top surgeons who hold parties where they drug-rape people. OK, maybe that's realistic, but then inviting one of their students was surely a pretty stupid idea? * Mary has the rapist all tied up, and is about to start torturing him. But instead they just cut away and we don't see him again until much later in the movie, after all the torture is finished. Why even go to all that effort of setting up that scene and then not going through with it? Did they run out of special effects budget? And she'd branded (or whatever) some word on his forehead; I presume it said "rapist" but I wouldn't know because it was illegible. * It seemed quite stupid for her to then take photos of the guy and say she was going to put them on her website. I mean, she knew the police were looking for him. Was it supposed to show she was losing her mind? * After showing no romantic interest in the strip-club owner whatsoever, she is suddenly about to kill some other chick just for giving him a blow-job. It was very hard to understand her motives. Was it supposed to show she was losing her mind? * The whole plot-line with the angry husband of the body-modified woman seemed like a random sub-plot until suddenly they used it to wrap up the whole film.
A lot of the reviews here seem to either love or hate this movie. I wouldn't say it worthy of either. It's a run-of-the-mill thriller movie (not a horror film at all IMO) and probably worth checking out if you can't find something better to watch.