Although The Simpsons did bring back Hank Scorpio more than once, his repeated returns never dented his status as the shows funniest one-off character. After 35 years on the air, The Simpsons has a cast of thousands. Most episodes of the show introduce a new character or two and, after over 740 episodes, this has resulted in a massive, sprawling cast for the animated sitcom. The Simpsons season 36 is likely to make this cast list even bigger, but not all the show's characters are created equal. There are some one-off guest stars who viewers will never forget.

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Some of the best one-off characters in the history of The Simpsons elevated their respective episodes and turned them into all-time classics.