The Futurama season 12 finale features a major Easter egg that references the Netflix series Disenchantment, and the connection between the two shows could have universe-altering implications. Matt Groening's three major TV shows, The Simpsons, Futurama, and Disenchantment, constantly reference each other despite the differing time periods, stories, and tones. While this is most commonly seen with Futurama and The Simpsons, Disenchantment has also had some tie-ins with the aforementioned shows, although Disenchantment's appearance in the Futurama season 12 finale is by far the show's biggest connection yet.

Futurama season 12, episode 10, "Otherwise" wraps up the second season of Hulu's Futurama revival, with it finally delving into a major sci-fi concept that has been teased for decades now: the multiverse. Although the multiverse has made appearances in previous Futurama episodes, "Otherwise" is the first one to fully explore it, with it following the Planet Express crew as they interact with a multiversal sea.