In what might be his biggest starring role in years since he was let go from the “Fantastic Beasts” franchise, Johnny Depp will star alongside Penélope Cruz in an action thriller for Lionsgate and director Marc Webb, the studio announced on Monday.

Depp and Cruz are teaming up on screen for what will be the fourth time in a thriller called “Day Drinker.” They previously starred together in “Blow,” “Pirates of the Caribbean: On Stranger Tides,” and “Murder on the Orient Express.”

“Day Drinker” follows a cruise ship bartender who meets a mysterious day drinker — only for both of them to find themselves entangled in a criminal underbelly, and connected in unexpected ways.

Webb is directing from an original spec screenplay by Zach Dean. Dean is the writer of “Fast X,” “The Tomorrow War,” “Deadfall,” and the upcoming “The Gorge” starring Anya Taylor-Joy.

The film is produced by “John Wick...