In the two-part "South Park" episode "Cartoon Wars" from 2006, it's revealed that an upcoming episode of "Family Guy" will feature the Prophet Muhammad as a character. The citizens of the titular town become terrified over the thought of military retaliation from various Islam-majority countries, since depictions of Muhammad are typically seen as blasphemous to many Muslim adherents. The episode came in the wake of a 2005 controversy when the Danish newspaper Jyllands-Posten published comic strips that depicted Muhammad, sparking protests and even riots.

By the end of the episode, the citizens of South Park are literally burying their heads in the sand, trying to prove that they haven't been looking at the "Family Guy" Muhammad episode. "South Park" creators Matt Stone and Trey Parker were trying to state, in their clumsy, cynical way, that it's silly to get offended by such things, and no one should be sensitive to the beliefs of others.