Jac is determined to make a complex operation a success on the day of a review meeting, Russ tries to find a new recipient after a liver transplant patients dies and Kylie bonds with a young woman who was mugged for her bike.
Jac is rushed into surgery after collapsing again during her failed presentation, Dominic takes his issues out on Alan and Fletch is torn between his loyalty to the staff and the management.
Nicky is distracted from treating a social media star by the news Jac is terminal, an operation on Flo gives Dominic and Sacha an idea to stop infections on stoma patients, and Fletch debates the job offer while helping a father and son.
Fletch is determined to get Harry his operation but attempts to transfer him end in disaster, Henrik is in a quandary after finding out Billie is pregnant and Sacha and Dominic struggle to work together on their research project.
Nicky gets pushed out of her comfort zone treating the daughter of one of Cameron's victims, Donna feels taken for granted after Jason is brought in as a patient, and Max schemes to get Josh involved in his and Ange's wedding plans.
Serena and Bernie return to look after Jason, Jac's expanded HDU scheme sees her determined to get an old acquaintance an operation, and an injury to Kylie while chasing a patient is the final straw for Donna.
Max deals with both a dismissive haematoma patient and Forbes' dismissive attitude to Billie being in pain, Josh's demons resurface when Claudia is brought in with a ruptured oesophagus and Eli is worried by Amelia's plans to adopt Juliet.
An anthrax threat leaves Jac and Nicky trapped in theatre and Henrik having to deliver Billie's baby in the conference room, while Ange begins to realise who the mole is.
Madge is suspended for whistleblowing but then collapses with internal bleeding, an encounter with a constipated patient on the waiting list leads to Dominic job seeking elsewhere and Russ feels guilty for not noticing Billie was pregnant.
With the hospital out of special measures, Jac admits she's dying. Regina tries to get dirt from Madge, Josh and Jeong-Soo debate the junior doctor award as they treat Lexi, and Billie wants to move to Leeds and Russ stay with Henrik.
Fletch summons Elliot back in a last ditch attempt to save Jac, while Jac accompanies Kylie to investigate Madge's home life. Donna asks for her job back after helping Jeong-Soo save Lexy from a tension pneumothorax.
Jac prepares for her surgery. Josh has an awkward encounter with Claudia's mother before he, Ange and Dominic treat a homeless Ken Davies. Lexy has a kidney match but Jeong-Soo finds a complication.
Time is running out for Jac and she makes a fateful choice. Dominic is determined to help Ken as he remains left out with Ange and Josh. Lexy gives Henrik food for thought.