Sort by Popularity - Most Popular Movies and TV Shows tagged with keyword "human-test-subject"
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1. The Amazing Spider-Man (2012)
PG-13 | 136 min | Action, Adventure, Sci-Fi
After Peter Parker is bitten by a genetically altered spider, he gains newfound, spider-like powers and ventures out to save the city from the machinations of a mysterious reptilian foe.
Director: Marc Webb | Stars: Andrew Garfield, Emma Stone, Rhys Ifans, Irrfan Khan
Votes: 702,685 | Gross: $262.03M
2. District 9 (2009)
R | 112 min | Action, Sci-Fi, Thriller
Violence ensues after an extraterrestrial race forced to live in slum-like conditions on Earth finds a kindred spirit in a government agent exposed to their biotechnology.
Director: Neill Blomkamp | Stars: Sharlto Copley, David James, Jason Cope, Vanessa Haywood
Votes: 717,140 | Gross: $115.65M
3. The Fly (1986)
R | 96 min | Drama, Horror, Sci-Fi
A brilliant but eccentric scientist begins to transform into a giant man/fly hybrid after one of his experiments goes horribly wrong.
Director: David Cronenberg | Stars: Jeff Goldblum, Geena Davis, John Getz, Joy Boushel
Votes: 202,038 | Gross: $40.46M
4. Venom (2018)
PG-13 | 112 min | Action, Adventure, Sci-Fi
A failed reporter is bonded to an alien entity, one of many symbiotes who have invaded Earth. But the being takes a liking to Earth and decides to protect it.
Director: Ruben Fleischer | Stars: Tom Hardy, Michelle Williams, Riz Ahmed, Scott Haze
Votes: 538,645 | Gross: $213.52M
5. Dark City (1998)
R | 100 min | Fantasy, Mystery, Sci-Fi
A man struggles with memories of his past, which include a wife he cannot remember and a nightmarish world no one else ever seems to wake up from.
Director: Alex Proyas | Stars: Rufus Sewell, Kiefer Sutherland, Jennifer Connelly, William Hurt
Votes: 212,384 | Gross: $14.38M
6. Max Payne (2008)
PG-13 | 100 min | Action, Crime, Drama
Coming together to solve a series of murders in New York City are a police detective and an assassin, who will be hunted by the police, the mob, and a ruthless corporation.
Director: John Moore | Stars: Mark Wahlberg, Mila Kunis, Beau Bridges, Ludacris
Votes: 130,205 | Gross: $40.69M
7. Dinner in America (2020)
106 min | Comedy, Drama, Music
An on-the-lam punk rocker and a young woman obsessed with his band unexpectedly fall in love and go on an epic journey together through America's decaying Midwestern suburbs.
Director: Adam Rehmeier | Stars: Kyle Gallner, Yancey Fuqua, Jennifer Kincer, Hannah Marks
Votes: 6,209
8. Cowboy Bebop: The Movie (2001)
TV-14 | 115 min | Animation, Action, Crime
A terrorist explosion releases a deadly virus on the masses, and it's up to the bounty-hunting Bebop crew to catch the cold-blooded culprit.
Directors: Shin'ichirô Watanabe, Mary Elizabeth McGlynn, Tensai Okamura, Hiroyuki Okiura, Yoshiyuki Takei | Stars: Beau Billingslea, Melissa Fahn, Nicholas Guest, Kôichi Yamadera
Votes: 53,184 | Gross: $1.00M
9. The Fly (1958)
Not Rated | 94 min | Drama, Horror, Sci-Fi
A scientist has a horrific accident when he tries to use his newly invented teleportation device.
Director: Kurt Neumann | Stars: David Hedison, Patricia Owens, Vincent Price, Herbert Marshall
Votes: 25,679 | Gross: $3.00M
10. Vile (2011)
R | 88 min | Horror, Mystery
Four friends are kidnapped by a madman and locked in a house with six other people. Each of the captives has to endure life-threatening torture to fill a device attached to their heads or they will be trapped inside forever.
Director: Taylor Sheridan | Stars: Eric Jay Beck, April Matson, Akeem Smith, Greg Cipes
Votes: 6,606
11. X: The Man with the X-Ray Eyes (1963)
Not Rated | 79 min | Horror, Sci-Fi, Thriller
A Roger Corman tale of Dr. James Xavier's devastating experiments on himself and the unforeseen.
Director: Roger Corman | Stars: Ray Milland, Diana Van der Vlis, Harold J. Stone, John Hoyt
Votes: 8,168
12. Open Grave (2013)
Unrated | 102 min | Horror, Mystery, Sci-Fi
A man wakes up with no memory in a pit full of dead bodies in the wilderness and must determine if the murderer is one of the strangers who rescued him, or if he himself is the killer.
Director: Gonzalo López-Gallego | Stars: Sharlto Copley, Thomas Kretschmann, Josie Ho, Joseph Morgan
Votes: 31,353
13. The Wasp Woman (1959)
Not Rated | 63 min | Horror, Sci-Fi
The head of a major cosmetics company experiments on herself with a youth formula made from royal jelly extracted from wasps, but the formula's side effects have deadly consequences.
Director: Roger Corman | Stars: Susan Cabot, Anthony Eisley, Barboura Morris, William Roerick
Votes: 5,476
14. Take the Money and Run (1969)
PG | 85 min | Comedy, Crime
The life and times of Virgil Starkwell, inept bank robber.
Director: Woody Allen | Stars: Woody Allen, Janet Margolin, Marcel Hillaire, Jacquelyn Hyde
Votes: 31,472 | Gross: $0.72M
15. Dark Fantasies (2010 Video)
TV-MA | 72 min | Drama
Broke College students take part in a paid sleep-induced study where their dark sexual fantasies are realized. But when the professor joined the scenarios, it turns into nightmare.
Director: Jay Robie | Stars: Steve Crest, Isabella Sky, Reena Sky, Joshua Broome
Votes: 87
16. The Killing Room (2009)
R | 93 min | Mystery, Thriller
Four individuals sign up for a psychological research study only to discover that they are now subjects of a brutal, classified government program.
Director: Jonathan Liebesman | Stars: Nick Cannon, Clea DuVall, Timothy Hutton, Chloë Sevigny
Votes: 14,917
17. Anti Matter (2016)
109 min | Horror, Mystery, Sci-Fi
A scientist faces the question of what makes us whole and if there is a part of us that is not part of this physical world when she discovers how to travel through a worm hole.
Director: Keir Burrows | Stars: Yaiza Figueroa, Philippa Carson, Tom Barber-Duffy, Noah Maxwell Clarke
Votes: 6,129
18. Infinitum: Subject Unknown (2021)
86 min | Mystery, Sci-Fi
An experimental film shot with just one crew member. Jane is trapped in a parallel universe and is forced to find a way to alter her reality before it is too late.
Director: Matthew Butler-Hart | Stars: Tori Butler-Hart, Ian McKellen, Conleth Hill, Wendy Muir Hart
Votes: 9,879
19. Testees (2008)
TV-MA | 30 min | Comedy
Two close friends are employed as guinea pigs for a pharmaceutical company. Each episode deals with the different "Research Products" given to the "Test Subjects". There are other stories playing throughout the seasons.
Stars: Jeff Kassel, Steve Markle, Joe Pingue, Kim Schraner
Votes: 2,655
20. The Mad Ghoul (1943)
Passed | 65 min | Horror, Sci-Fi, Thriller
A university chemistry professor experiments with an ancient Mayan gas on a medical student, turning the would-be surgeon into a murdering ghoul.
Director: James P. Hogan | Stars: David Bruce, Evelyn Ankers, George Zucco, Robert Armstrong
Votes: 891
21. On the Threshold of Space (1956)
Approved | 98 min | Drama
Scientist is sent to investigate a faulty ejector seat, then sent into space to test it, showing an assortment of human weaknesses and strengths. Basically this is about the human predicament and drama, not space.
Director: Robert D. Webb | Stars: Guy Madison, Virginia Leith, John Hodiak, Dean Jagger
Votes: 264
22. Before I Hang (1940)
Passed | 62 min | Crime, Horror, Sci-Fi
A physician on death row for a mercy killing is allowed to experiment on a serum using a criminals' blood, but secretly tests it on himself. He gets a pardon, but finds out he's become a Jekyll-&-Hyde.
Director: Nick Grinde | Stars: Boris Karloff, Evelyn Keyes, Bruce Bennett, Edward Van Sloan
Votes: 1,416
23. Mutants (2008)
R | 83 min | Action, Horror, Sci-Fi
A mad scientist inadvertently unleashes the apocalypse while attempting to create an addictive additive for a greedy manufacturer.
Director: Amir Valinia | Stars: Michael Ironside, Louis Herthum, Tony Senzamici, Steven Bauer
Votes: 644
24. Psi-Ops: The Mindgate Conspiracy (2004 Video Game)
M | Action, Adventure, Sci-Fi
A psychic terrorist organization is bent on taking over the world, and a lone soldier, with altered memories and suppressed psychic abilities, is sent to infiltrate and stop their plans at all costs.
Directors: Mo Davoudian, Martin Stoltz | Stars: Steve Matuszak, Joanna Buese, Greg Whalen, Jerry Bloom
Votes: 225
25. Reign in Darkness (2002 Video)
R | 90 min | Action, Horror, Sci-Fi
Molecular biologist Michael Dorn is accidentally infected with a new virus he is developing, turning him and its other victims into a new breed of vampire.
Directors: David W. Allen, Kelly Dolen | Stars: Kelly Dolen, David W. Allen, David Will No, Chris Kerrison
Votes: 440
26. Breakdown (2004 Video Game)
M | Action, Adventure, Fantasy
First person fighting and shooter game for X-Box about a man with amnesia waking up in a strange testing facility and learning from a mysterious female ally that he must stop an alien invasion.
Director: Masafumi Shibano | Stars: Steve Kramer, Steve Apostolina, Beau Billingslea, Steve Blum
Votes: 80
27. Subject #7 (2017)
18 min | Short, Horror, Mystery
A woman awakens alone in the woods with a strange headache, and an odd marking on her body.
Director: Leeroy C. Farrare | Star: Alex Fandel
Votes: 10
28. To Dust (2014– )
Animation, Action, Drama
Five years. It has been five years since the end of the Great War. The land is mostly unrecoverable, amounts of dirt unable to grow things, almost everything a vast desert. One stretch of ... See full summary »
Stars: Michael Hall, David Reiverson, Dallas Reid, Rebekah Amber Clark
30. Strange Visitors & Other Tales (2001 Video)
75 min | Adventure
Three bondage-filled vignettes from Harmony Concepts. In the first two beautiful aliens, one good and one evil, keep a lovely Earthling bound and silenced. In the second, a scientist ... See full summary »
Director: Jon Woods | Stars: Kat Le, Sirena Scott, Oceane, Sadie Atkins
31.
PSI Factor: Chronicles of the Paranormal (1996–2000)
Episode:
Old Wounds
(1999)
TV-14 | 45 min | Drama, Fantasy, Mystery
A woman is somehow physically injured by the virtual reality space shooter game she's testing with its programmer. The team suspects that the game triggered suppressed traumatic memories of her life in communist China in 1989.
Director: Luc Chalifour | Stars: Matt Frewer, Nancy Anne Sakovich, Barclay Hope, Colin Fox
Votes: 16
32.
The Avengers (1961–1969)
Episode:
The Deadly Air
(1961)
TV-14 | 52 min | Action, Comedy, Crime
When a revolutionary, but experimental, vaccine is stolen from a top-secret laboratory and a volunteer who was administered a dose dies, Keel and Steed agree to be human guinea pigs for the next test.
Director: John Knight | Stars: Ian Hendry, Patrick Macnee, Ingrid Hafner, Keith Anderson
Votes: 31
33.
Monsters (1988–1990)
Episode:
Habitat
(1990)
TV-14 | 21 min | Comedy, Drama, Fantasy
A woman agrees to be an alien test subject, only to lose her mind with loneliness.
Director: Bette Gordon | Stars: Lili Taylor, Frederick Wessler
Votes: 96
34.
The Outer Limits (1995–2002)
Episode:
The Awakening
(1997)
TV-PG | 45 min | Drama, Fantasy, Horror
A woman born with a condition that prevents her from accessing her feelings has a chip installed in her brain so that she can experience human emotion.
Director: George Bloomfield | Stars: Lela Rochon, Gordon Pinsent, Michele Greene, Roger Cross
Votes: 271
35.
PSI Factor: Chronicles of the Paranormal (1996–2000)
Episode:
883
(1999)
TV-14 | 45 min | Drama, Fantasy, Mystery
Matt finds a disfigured mute with number 883 embedded on his arm. His toxic blood infects Matt and slowly starts killing him. Matt's only chance for survival is the secretive female doctor behind the genetic experiment that created 883.
Director: Ron Oliver | Stars: Matt Frewer, Nancy Anne Sakovich, Barclay Hope, Joanne Vannicola
Votes: 18
36.
Tales from the Crypt (1989–1996)
Episode:
Smoke Wrings
(1996)
Not Rated | 30 min | Comedy, Crime, Fantasy
A young man with a strange device is hired onto an advertising company by an esteemed executive--but what the exec doesn't know is that the young man is in cahoots with her enraged ex-partner who is out for revenge.
Director: Mandie Fletcher | Stars: Ute Lemper, Chris Stanton, Tres Hanley, Daniel Craig
Votes: 506
37.
Courage the Cowardly Dog (1999–2002)
Episode:
Courage Meets Bigfoot/Hothead
(1999)
TV-Y7 | 23 min | Animation, Adventure, Comedy
"Courage Meets Bigfoot" A hungry Bigfoot turns up at the farm. Courage is terrified at first, but befriends the gentle monster and must save him from the Farmer and an angry mob.
Director: John Dilworth | Stars: Marty Grabstein, Lionel Wilson, Thea White, Jason Antoon
Votes: 452
38.
Home Movies (1999–2004)
Episode:
Writer's Block
(2002)
TV-PG | 23 min | Animation, Comedy, Drama
Brendan, suffering from writer's block, becomes increasingly anxious as the school Writer's Fair nears. Meanwhile, his mother works on her own work - a romance novel - and Coach McGuirk, ... See full summary »
Director: Loren Bouchard | Stars: Brendon Small, H. Jon Benjamin, Melissa Bardin Galsky, Janine Ditullio
Votes: 88
39.
The Flash (2014–2023)
Episode:
A Flash of the Lightning
(2019)
TV-PG | 42 min | Action, Adventure, Drama
Faced with the news of his impending death, Barry's resiliency suffers as he struggles to fight fate; Cecile's career as a D.A. conflicts with her identity when she crosses paths with a villainous meta-human.
Director: Chris Peppe | Stars: Grant Gustin, Candice Patton, Danielle Panabaker, Carlos Valdes
Votes: 2,322
40.
The Big Bang Theory (2007–2019)
Episode:
The Pork Chop Indeterminacy
(2008)
TV-PG | 22 min | Comedy, Romance
Leonard, Howard and Raj fight over Sheldon's twin sister when she arrives in town. Raj takes part in a drug trial to suppress his selective mutism.
Director: Mark Cendrowski | Stars: Johnny Galecki, Jim Parsons, Kaley Cuoco, Simon Helberg
Votes: 4,887
41.
Smash Lab (2007– )
Episode:
High Rise Escape
(2008)
TV-PG | 44 min | Reality-TV
The Smash Lab team tries to devise a fire escape for skyscrapers using nothing more than magnetism.
Director: Damon Zwicker | Stars: Deanne Bell, Nick Blair, Kevin Cook, Chuck Messer
42.
Fringe (2008–2013)
Episode:
The Cure
(2008)
TV-14 | 65 min | Drama, Mystery, Sci-Fi
A number of people in a diner die of radiation exposure and Olivia and the Bishops believe a woman who disappeared two weeks earlier was the source.
Director: Bill Eagles | Stars: Anna Torv, Joshua Jackson, Lance Reddick, Kirk Acevedo
Votes: 2,743
43.
House M.D. (2004–2012)
Episode:
Adverse Events
(2008)
TV-14 | 44 min | Drama, Mystery
House's investigator gets information on everyone, which House uses to stir the pot of their lives while the team tries to cure a portraitist whose artistic view now looks like Picasso.
Director: Andrew Bernstein | Stars: Hugh Laurie, Lisa Edelstein, Omar Epps, Robert Sean Leonard
Votes: 2,554
44.
Testees (2008)
Episode:
Gas Pills
(2008)
TV-MA | 30 min | Comedy
After testing a radical new pill for Testico, the boys discover there is a miracle growing inside Peter.
Director: Samir Rehem | Stars: Jeff Kassel, Steve Markle, Joe Pingue, Kim Schraner
Votes: 80
45.
Futurama (1999– )
Episode:
Neutopia
(2011)
TV-14 | 22 min | Animation, Adventure, Comedy
To avoid an imminent bankruptcy, the "Planet Express" is converted into an airline company, but on its the first flight the airliner crash-lands on a strange planet.
Director: Edmund Fong | Stars: Billy West, Katey Sagal, John DiMaggio, Tress MacNeille
Votes: 2,187
46.
The Whistler (1954– )
Episode:
Sleep My Pretty One
(1955)
Mystery
Newly engaged Cora James learns from a fortune teller that she has no future after March 13 (a few days away), then her scientist fiancé is talking about a human test subject for his new ... See full summary »
Director: William F. Claxton | Stars: Martha Vickers, Paul Langton, Sarah Padden, Nan Boardman
Votes: 9
47.
It's Always Sunny in Philadelphia (2005– )
Episode:
Flowers for Charlie
(2013)
TV-MA | 21 min | Comedy
When an experiment successfully multiplies Charlie's intellect and takes him away from the bar, the rest of the gang find themselves struggling to complete the menial 'Charlie Work' that has kept the bar running for so long.
Director: Daniel Attias | Stars: Charlie Day, Glenn Howerton, Rob McElhenney, Kaitlin Olson
Votes: 3,260
48.
Fugget About It (2012–2021)
Episode:
The McFrugals
(2013)
TV-MA | 22 min | Animation, Comedy, Crime
Jimmy gets a credit card and takes his family on a spending spree.
Director: Richard Weston | Stars: Tony Nappo, Jacqueline Pillon, Chuck Shamata, Emilie-Claire Barlow
Votes: 40
49.
Helix (2014–2015)
Episode:
Ectogenesis
(2015)
TV-PG | 43 min | Drama, Horror, Mystery
Walker and Balleseros arrive at the Abbey while Alan, Kyle and Winger are out in the woods searching for the tree with red sap that might be a cure for the pathogen.
Director: Jeremiah S. Chechik | Stars: Billy Campbell, Kyra Zagorsky, Matt Long, Mark Ghanimé
Votes: 316
50.
Manifest (2018–2023)
Episode:
Dead Reckoning
(2018)
TV-14 | 42 min | Drama, Mystery, Sci-Fi
When Ben and Michaela put everything on the line to save the other missing passengers, the mission goes horribly awry.
Director: Paul Holahan | Stars: Melissa Roxburgh, Josh Dallas, Athena Karkanis, J.R. Ramirez
Votes: 1,873